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Sunday, August 11 • 4:25pm - 5:00pm
BioKDD: Invited talk 2: Systems Biology of Cellular Aging and Age-Related Degeneracies : Ananth Grama, Purdue University

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Ananth Grama, Purdue University will deliver a talk titled Systems Biology of Cellular Aging and Age-Related Degeneracies. His summary of the talk: Cellular aging is a multi-factorial complex phenotype, characterized by the accumulation of damaged cellular components over the organism's life-span. The progression of aging depends on both the increasing rate of damage to DNA, RNA, proteins, and cellular organelles, as well as the gradual decline of the cellular defense mechanisms against stress. This can ultimately lead to a dysfunctional cell, with a higher risk factor for a number of diseases, including cancers, cardiovascular disease, and multiple neurodegenerative disorders. With a view to uncovering the pathways associated with aging, and their role in age-related degeneracies, we have developed a number of algorithms and statistical models that integrate and analyze disparate data over human and yeast interactomes. In this talk, we present two recent results: (i) we demonstrate the use of directed random walks in uncovering the downstream effectors of Target of Rapamycin (TOR), a highly conserved protein kinase that plays a key role in the aging process of various organisms; and (ii) we build tissue-specific networks for human cells and develop a complete framework for projecting these tissue-specific networks on to the yeast interactome. The goals of this effort are many-fold -- strong alignments indicate tissues for which yeast is a good model organism (in terms of underlying biochemistry), alignments reveal specific pathways that are well conserved, and they serve as a first step in understanding the etiology of age-related degeneracies.

Sunday August 11, 2013 4:25pm - 5:00pm CDT

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